Indeed, results from a recent study using RNA sequencing and Western Blot analysis showed that mice lacking IL-20R expression were more susceptible to DSS-induced colitis, and IL-20 levels were induced during remission in IBD patients and especially in those who responded to anti-TNF treatment [17].In our study, the IL-24 expression was increased in UC patients after treatment with biologics and was statistically related with the Mayo Score (p<0.05). Here, TNF is linked to colitis.