CD79A and hereditary spastic paraplegia: The main clinical features include round or oval-shaped palpable purpura predominantly on the lower legs, joint pain or arthritis, gastrointestinal bleeding or pain, and IgA deposition in the mesangium leading to glomerulonephritis [10]. In China, traditional Chinese medicine (TCM) has been used in the extensive treatment of HSP, and DD is a representative prescription drug.