Intriguingly, it was demonstrated that the nematode homologue of PGRMC1, VEM-1, physically interacts with C. elegans UNC-40, the nematode homologue of the mammalian cell surface receptor ‘deleted in colorectal cancer’ (DCC) [55], which is one of the receptors mediating netrin-1 function [56]. The gene discussed is PGRMC1; the disease is cancer.