Zhang et al. have developed a dual-channel electrochemical immunosensor capable of detecting and measuring the presence of both IL-1β and MMP-8 in saliva as a POCT to aid in the rapid and accurate diagnosis of periodontitis.78 The simultaneous determination of the levels of these biomarkers synchronously allows for higher accuracy in diagnosing the current stage of periodontitis.78 Tested against both spiked artificial saliva and clinical samples, the device has high sensitivity and a wide linear range using IrOx/Ti3C2Tx nanocomposites. Here, MMP8 is linked to periodontitis.