These criteria include (1) HBeAg-positive CHB patient with abnormal ALT levels combined HBV-DNA > 20,000 IU/mL, (2) HBeAg-negative CHB patient with abnormal ALT levels combined HBV-DNA > 2,000 IU/mL, (3) CHB patient with cirrhosis concomitant with obvious evidence of portal hypertension, and (4) meet the criteria of acute on chronic liver failure. The gene discussed is GPT; the disease is liver disorder.