AFP and cancer: In terms of HCC development, male (adjusted hazard ratio [aHR]: 1.99, 95% CI: 1.64-2.41; P<0.001), age (aHR: 1.05, 95% CI: 1.04-1.05; P<0.001), Those with other cancers aHR: 1.24, 95% CI: 1.06-1.46; P=0.009), those with liver cirrhosis (aHR: 2.86, 95% CI: 2.37-3.43; P<0.001), Platelet (aHR: 1.63, 95% CI: 1.36-1.95; P<0.001), AST (aHR: 2.09, 95% CI: 1.62-2.69; P<0.001), and AFP (aHR: 11.72, 95% CI: 8.16-16.84; P<0.001) are independent significant predictors.