Possibly, since C‐C is more inert than C‐N, Ψ’s “reader” and “writer” proteins are less detectable than other modifications.∖Mutations in the DKC1 enzyme in the Ψ‐mediated catalytic mode by RNA‐dependent mechanisms are associated with aberrant protein translation and have been reported to be upregulated in a variety of cancers.407, 419. Here, DKC1 is linked to cancer.