IGF-1 is one of the potent activators of cellular proliferation via the protein kinase B signaling pathway, an inhibitor of apoptosis, and exerts a mitogenic effect via the activation of mitogen-activated protein kinases and expression of proto-oncogenes [11]. Hepatic lipid accumulation in obesity has been linked to lipotoxicity, which interferes with cellular signaling mechanisms and regulation of gene transcription, leading to the activation of oncogenic pathways. Here, WNK2 is linked to obesity due to melanocortin 4 receptor deficiency.