Some of the leading systems include the Medtronic MiniMed 780G (Medtronic, Dublin, Ireland), Tandem Diabetes Care's t:slim X2 with Control-IQ (Tandem Diabetes Care, Inc., San Diego, CA), and the Omnipod 5 Automated Insulin Delivery System (Insulet Corporation, Acton, MA). The gene discussed is INS; the disease is diabetes mellitus.