This review aims to provide a comprehensive overview of the recent advancements in endocrine drug delivery technologies, including inhaled insulin, peptide-based drugs, RPs, implantable devices, wearable artificial pancreas systems, smart insulin pens, microneedle patches, and hydrogels. By examining how effective and safe these new methods are, along with their benefits and limitations, we hope to show how they can transform the treatment of endocrine disorders and improve patient outcomes. The gene discussed is INS; the disease is endocrine system disorder.