Yao syndrome, identified in 2011 by Yao et al. and previously known as nucleotide-binding oligomerization domain-containing protein 2 (NOD2)-associated autoinflammatory disease, is an autoinflammatory disease characterized by periodic fevers and abnormal inflammation affecting multiple body systems, particularly the skin, joints, and gastrointestinal system, driven by dysregulation within the innate immune system [1]. This evidence concerns the gene NOD2 and Yao syndrome.