To explore whether ENST00000353555 exerts isoform-specific regulation on the immunosuppression, we compared the correlation of total BSG expression and ENST00000353555 with 24 immunosuppressive genes identified in a previous publication [21], including VTCN1, ARG1, EDNRB, IL12A, CD274, HAVCR2, IL10, CTLA4, SLAMF7, TIGIT, BTLA, IDO1, LAG3, PDCD1, IL13, IL4, KIR2DL1, KIR2DL3, ADORA2A, C10orf54, VEGFB, VEGFA, CD276, and TGFB1, in primary liver cancer cases in TCGA-LIHC (Figure 3). The gene discussed is TIGIT; the disease is liver cancer.