The reported major risk factors for SJS and TEN include (i) possessing a slow acetylator genotype, which has been associated with accelerated susceptibility to certain autoimmune diseases (ADs), (ii) the presence of immune-suppression, which describes a weak prognosis in the advancement of SJS/TEN, (iii) usage of anti-convulsant agents concurrent with radiotherapy and (iv) possessing specific human leukocyte antigen (HLA) alleles like HLA-B x 15:02, HLA-A x 31:01 and HLA-B x 58:01 [4]. This evidence concerns the gene HLA-A and toxic epidermal necrolysis.