ICU: intensive care unit; MV: mechanical ventilation; IMV: invasive mechanical ventilation; AKI: acute kidney injury; CKD: chronic kidney injury; RRT: renal replacement therapy; HD: hemodialysis; LDH: lactate dehydrogenase; CRP: C-reactive protein; WBC: white blood cell count; PCT: procalcitonin. The gene discussed is CRP; the disease is acute kidney injury.