The SSc-PBC meta-analysis statistics in CAST/ERAP1 and SPPL3 loci colocalized with reduced transcripts of endoplasmic reticulum aminopeptidase 1 (ERAP1), increased transcripts of endoplasmic reticulum aminopeptidase 2 (ERAP2) and reduced transcripts of signal peptide peptidase-like 3 (SPPL3). The gene discussed is CAST; the disease is primary biliary cholangitis.