TG and obesity due to melanocortin 4 receptor deficiency: Given that HT is not always associated with pathological values in TSH and thyroid hormones, as demonstrated in The POUNDS LOST Trial, it appears that even euthyroid patients with overweight or obesity and relatively lower levels of free T3 and free T4 may derive less benefit from dietary interventions aimed at weight loss compared to those with higher levels, and vice versa.