TPO and obesity due to melanocortin 4 receptor deficiency: An intervention involving a 6-month dietary regimen of 1400–1600 kcal, coupled with daily supplementation of selenium and zinc (2–4 times higher than the Recommended Dietary Allowance for the general population), in women with obesity previously diagnosed with HT and receiving levothyroxine treatment (with one-third on euthyroid status at baseline), resulted in significant reductions in weight, BMI, body fat percentage, as well as TSH, anti-TG, and anti-TPO levels, alongside a concurrent increase in free triiodothyronine (fT3) and free thyroxine (fT4) levels (112).