Building on published studies which identify the role that the spleen tyrosine kinase (SYK) plays in modulating microglial responses to AD-associated Aβ deposition (Ennerfelt et al., 2022) and neuroinflammation (Chu et al., 2021), through the PI3K/AKT/GSK3β signaling pathway, our studies identify a potential role for DUSP6 modulation of the ERK signaling pathway in the mitigation of AD-associated Aβ deposition, neuroinflammation, and AD-associated microglial responses. Here, SYK is linked to Alzheimer disease.