Several of the DEGs, upregulated by DUSP6 overexpression in male but not female 5xFAD-DUSP6 mouse hippocampus, include Baiap3, Oprk1, Hap1, Fxyd6, Adra2a, Efnb2, Actn2, Nos1, Grin3a, Mapk3, Slc6a7, and Cadm1. All of these have been associated with either AD or other neurodegenerative diseases (Reif et al., 2011; Chen et al., 2014; Ji et al., 2015; Jin et al., 2019; Ting et al., 2019; Aykac and Sehirli, 2020; Lee and Lee, 2020; Georgakopoulos et al., 2021; Muraoka et al., 2021; Kim H. et al., 2022; Zhong et al., 2022; Zhang J. et al., 2023). This evidence concerns the gene OPRK1 and Alzheimer disease.