BAIAP3 and major depressive disorder: Baiap3 dysregulation has been associated with both major depressive disorder (Kim H. et al., 2022) and AD (Lalli et al., 2012), and it is regulated in a sex-dependent manner in mouse models and human subjects with anxiety (Wojcik et al., 2013), and also plays a role in the recovery from CNS injury (Lauridsen et al., 2011).