Previously, members of our team at Mount Sinai used multiscale causal network-based approaches to identify the dual specificity protein phosphatase 6 (DUSP6), also known as mitogen-activated protein kinase (MAPK) phosphatase 3 (MKP3), as a key hub in the VGF gene network that regulates AD (Beckmann et al., 2020). Here, VGF is linked to Alzheimer disease.