DUSP6 is downregulated in several neurological and neuropsychiatric diseases including AD (Banzhaf-Strathmann et al., 2014), schizophrenia (Kondo et al., 2022), and major depressive disorder (Labonte et al., 2017), the latter frequently co-morbid with AD (Martín-Sánchez et al., 2021; Arnaud et al., 2022). Here, DUSP6 is linked to major depressive disorder.