Van Hage confirmed that the oligosaccharide previously identified as an IgE‐binding epitope on cat IgA was α‐gal.[13] Since α‐gal epitopes are widely expressed in the cells and tissues of nonprimate mammals but not in human or monkey tissues, α‐gal‐specific IgE may be a primary allergen of mammalian meat; thus, alpha‐gal may be a primary allergen for allergy to a wide spectrum of mammalian meats in humans.[4]. Here, IGHE is linked to allergic disease.