We found that the validated model of INHBA had an AUC value of 0.927 for the ROC curve, HSP90AA1 had an AUC value of 0.934, and ELF2AK2 had an AUC value of 0.871, whereas the LRRK2 and HSPB8 models had lower AUC values of the ROC curve (0.517 and 0.536, respectively) (Fig. S1B).These results suggest that the hub genes we identified have a high potential for diagnostic efficacy in ESCC. The gene discussed is HSP90AA1; the disease is esophageal squamous cell carcinoma.