Particularly, the expression of INHBA, HSP90AA1 and EIF2AK2 in ESCC cancer tissues was significantly higher than that in normal tissues, while the level of LRRK2 and HSPB8 in ESCC tissues was remarkably lower as compared to the normal tissues (Fig. 3C). The gene discussed is EIF2AK2; the disease is esophageal squamous cell carcinoma.