In COAD, the expression of SLC24A1 gradually decreased from stage I to IV, while SLC8A2 expression increased from stage I to IV in COAD, and the expressions of SLC8B1, SLC8A1, SLC8A3, SLC24A2, SLC24A3, SLC24A4 and SLC24A5 did not show significant differences among different tumor stage (Fig. 3). The gene discussed is SLC8A1; the disease is neoplasm.