In COAD, the expression of SLC24A1 gradually decreased from stage I to IV, while SLC8A2 expression increased from stage I to IV in COAD, and the expressions of SLC8B1, SLC8A1, SLC8A3, SLC24A2, SLC24A3, SLC24A4 and SLC24A5 did not show significant differences among different tumor stage (Fig. 3). This evidence concerns the gene SLC8A3 and neoplasm.