In conclusion, BSI should be taken seriously in patients with erythroderma, especially in cases with risk factors such as abnormal temperature (≤36.0 or ≥38.5 °C), chilling, kidney disease, the etiology of drug reactions, elevated CRP (≥32 mg/L) and PCT (≥1.00 ng/ml), and low ALB (≤31.0 g/L). Here, ALB is linked to exfoliative dermatitis.