piRNAs were also linked with the dysregulation of different AD-associated pathways, such as pituitary adenylate cyclase activating polypeptide (PACAP) signaling in neurons, axonal transport, and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor trafficking (Sato et al., 2023). The gene discussed is ADCYAP1; the disease is Alzheimer disease.