For instance, a study found that interferon-γ (INF-γ) was the dominant driver of the expression of signaling lymphocytic activation molecule family member 7 (SLAMF7, CD319), whose engagement drove a strong wave of inflammatory cytokine expression in macrophages, and that SLAMF7-induced gene programs existed in gut macrophages from patients with active CD and in lung macrophages from patients with severe COVID-19 (Simmons et al., 2022). This evidence concerns the gene SLAMF7 and COVID-19.