INS and cancer: The enrichment results from Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that many signaling pathways were altered due to SD including a number of important signaling pathways including PI3K-Akt signaling pathway, Hedgehog signaling pathway, cGMP-PKG signaling pathway and phospholipase D signaling pathway, many basic processed associated with cellular physiology including actin cytoskeleton, focal adhesion, cell cycle, protein processing in endoplasmic reticulum, and metabolic pathways including choline metabolism in cancer, insulin signaling pathway and metabolic pathways.