OPN1MW and major depressive disorder: While risk of publication bias was indicated for four of the meta-analytical models (Egger’s test P < 0.05) (Supplementary Fig. 3), an inspection of trim-and-fill adjusted estimates did not alter the conclusions for (1) administration of a single dose of THC (PEgger < 0.0001, dunadjusted = 0.7, dtrim-and-fill = 0.49), (2) CBD administration (PEgger = 0.0001, dunadjusted = −0.19, dtrim-and-fill = −0.14, both P < 0.05), psychosis liability (PEgger = 0.025, dunadjusted = 0.49, dtrim-and-fill = 0.49), and (3) diagnosis of depression (PEgger = 0.019, dunadjusted = 0.37, dtrim-and-fill = 0.54).