DEFB1 and hydrops fetalis: Many of the sperm transcripts of β-defensins such as DEFB-1, 7, 123, 124, 119 and DEFB-110 have been reported to be highly expressed in HF bulls and thus implicated in the regulation of male fertility (Binsila et al., 2021; Ma et al., 2019; Hou et al., 2019; Paul et al., 2021).