We identified a total of 11 obesity associated genes showing enriched expression in hypothalamic neurons, including ACHE, ERBB4, GRID1, KCNK3, KCNK9, KSR2, NRXN3, NTRK2, PLXNA4, POMC and STX1B (Fig. 4E). Here, KCNK3 is linked to obesity due to melanocortin 4 receptor deficiency.