We identified a total of 11 obesity associated genes showing enriched expression in hypothalamic neurons, including ACHE, ERBB4, GRID1, KCNK3, KCNK9, KSR2, NRXN3, NTRK2, PLXNA4, POMC and STX1B (Fig. 4E). The gene discussed is STX1B; the disease is obesity disorder.