The majority of genes upregulated in HCV tumor-adjacent tissue, except IFI27, IFI6, and PLA2G2A, show average expression below 1 TPM in GTEx normal liver samples, suggesting that the upregulation of these immune-related genes in HCV tumor-adjacent tissue is likely mediated by the viral infection (Supplementary Figure 1V). Here, IFI27 is linked to neoplasm.