Similarly, only forced expression of TRIM65‐WT could increase the infiltration of M2 macrophages and down‐regulate infiltration of CD8+ T cells, M1 macrophages, and natural killer (NK) cells (Figure 7N‐O; Figure S6I, Supporting Information), demonstrating that TRIM65 induced a tolerant immune microenvironment in HCC relying on its E3 ligase activity. The gene discussed is TRIM65; the disease is hepatocellular carcinoma.