As expected, UMPS expression was markedly decreased by TRIM65 deficiency in HCC cells (Figure 6C), which was consistent with downstream YAP1 targets such as cysteine‐rich angiogenic inducer 61 (CYR61),[32] connective tissue growth factor (CTGF),[33] and G1/S‐specific cyclin‐D1 (CCND1)[34] (Figure S5C, Supporting Information). Here, CCN1 is linked to hepatocellular carcinoma.