ME2 and neoplasm: ME2 has previously been reported to promote l‐2‐HG production in tumor cells.[31] Since ME2 is localized in the mitochondria, ME2‐mediated l‐2‐HG production was speculated to be mitochondria‐specific.[31] To verify this hypothesis, ME2 was coexpressed with sfLHGFRH in HEK293FT cells (Figure S10c, Supporting Information).