MRC1 and neoplasm: The 3 necrosis evaluation methods mainly showed similar associations with tumor and patient characteristics, including high stage, MMR proficient status, BRAF wild-type status, nonmucinous/nonsignet ring cell histology, and high tumor grade (all P<0.001) (Table 1; and Table S1, Supplemental Digital Content 2, http://links.lww.com/PAS/B910, Table S2, Supplemental Digital Content 3, http://links.lww.com/PAS/B911).