SIRT2 and Insulin resistance: Therefore, we performed a glucose tolerance test (GTT) and insulin tolerance test (ITT) on Sirt2-/- and control mice [30], and found that glucose tolerance and insulin resistance were more severe in Sirt2-/- mice (Fig. 1G H); Sirt2-/- mice also showed a slower decline and faster rebound of blood glucose, which implies possible insulin resistance.