By integrating and analyzing marker genes from published literature, we successfully identified seven significant immune cell populations, including B cells, CD8+ T, CD4+ T, Treg, Momo.macro, NK, and Plasma cells, and further analyzed the differentially expressed genes and their functions in the seven major cell types in DLBCL (Fig. 6A and Supplementary Fig. 14A-B). The gene discussed is CD8A; the disease is diffuse large B-cell lymphoma.