INS and type 1 diabetes mellitus: The treatment of diabetes, in particular that of type 1 diabetes, has deeply changed due to the increasingly use of technologies both for continuous glucose monitoring (CGM), and for continuous insulin infusion (Continuous Subcutaneous Insulin Infusion, CSII) and their integration through the use of automatic systems equipped with algorithms (Advance Hybrid Closed Loop, AHCL) [1–4].