It was found that the tumor microenvironment (TME) of EGFR-mutated NSCLC showed a "cold" phenotype [10, 11], including low expression of PD-L1 on tumor cells, low infiltration of CD8+ T cells, and high infiltration of immunosuppressive regulatory cells in the TME. The gene discussed is CD8A; the disease is non-small cell lung carcinoma.