In contrast, a recent publication (Hou et al. [23]) reported that AML induced by BCR-ABL, AML1-ETO, and MLL-AF9 fusions is impaired by Phf6 loss, reaching the counterintuitive conclusion that Phf6 is required for myeloid leukemogenesis. The gene discussed is RUNX1; the disease is acute myeloid leukemia.