We confirmed that Ctrl+Hoxa9 marrow produced lethality in recipient mice in ~3–5 months after transplantation (Fig. 1E) due to AML characterized by >20% blasts in the marrow (Fig. S2C), peripheral leukocytosis (Fig. S2D), splenomegaly with effacement of splenic architecture (Fig. S2E), and infiltration of leukemic cells in the liver (Fig. S2F). Here, HOXA9 is linked to acute myeloid leukemia.