PHF6 and leukemia: The latter publication reporting the counterintuitive finding that Phf6 loss reduces AML growth and stemness contradicts the model of PHF6 as a leukemia suppressor; however, the publication’s use of fusion protein drivers that do not co-occur with human PHF6 mutations may indicate that the chosen AML models recapitulated narrow disease subsets potentially not reflective of broader AML biology.