We confirmed that Ctrl+Hoxa9 marrow produced lethality in recipient mice in ~3–5 months after transplantation (Fig. 1E) due to AML characterized by >20% blasts in the marrow (Fig. S2C), peripheral leukocytosis (Fig. S2D), splenomegaly with effacement of splenic architecture (Fig. S2E), and infiltration of leukemic cells in the liver (Fig. S2F). The gene discussed is CTRL; the disease is acute myeloid leukemia.