NOTCH1 and acute lymphoblastic leukemia: Combination of Phf6 loss with overexpression of activating mutants of Notch1 [18] or Jak3 [20], or overexpression of wildtype Tlx3 [17] has been shown to cause T-ALL acceleration, while transgenic crosses of Phf6 deletion with Idh2 mutation produce mixed myeloid-lymphoid leukemias [21].