To assess the role of PHF6 loss in mouse AML, we generated conditional hematopoietic Phf6 knockout Vav-CreCre/+Phf6fl/y (cKO) mice (Fig. S1D) and compared them to their Vav-CreCre/+Phf6+/y (Ctrl) littermates. This evidence concerns the gene VAV1 and acute myeloid leukemia.