Somatic PHF6 mutations are seen in 38% of T-cell acute lymphocytic leukemia (T-ALL) [9], in 3–6% of AML, myelodysplastic syndrome (MDS), and chronic myelomonocytic leukemia (CMML), and in 23% of mixed-phenotype acute leukemia (MPAL) and undifferentiated leukemia [10–16]. This evidence concerns the gene PHF6 and acute myeloid leukemia.