IGHE and granular corneal dystrophy type II: The findings that cases with positive t-tIgE or c-Eo showed significantly more objective symptoms’ JACQLQ score than those with negative t-tIgE or c-Eo, respectively, indicates that the importance of local IgE and eosinophil in the development and deterioration of ACD which could be confirmed by subjective score system (Fig. 3).