Besides, it was revealed that these cells exhibit multiple functions, including the production of IFN-gamma, TNF-alpha, and granzyme B. Notably, there were no indications of physiological depletion, and these findings were found to be correlated with the activity of immune thrombocytopenia (ITP) disease [40]. The gene discussed is TNF; the disease is autoimmune thrombocytopenic purpura.