Taken together, these results suggest that the beneficial effects of TBC depend on B3galt5, confirming B3galt5 is the messager conducting intestinal PXR function and the PXR-B3galt5 axis is vital for intestinal barrier maintenance, thus preventing the occurrence of obesity and inflammation. The gene discussed is B3GALT5; the disease is obesity due to melanocortin 4 receptor deficiency.