Previous links between path_MMR and BC may be caused by higher rates of mammographic screening in individuals with a family history of LS-associated cancers, such as ovarian, leading to overdiagnosis.15 Additionally, due to their population frequencies, path_MSH6 and path_PMS2 may often be incidentally identified in individuals undergoing multigene hereditary cancer screening. Here, PMS2 is linked to hereditary cancer.