If path_MLH1 and path_MSH2 carriers are more likely to be affected by cancer than path_MSH6 and path_PMS2 carriers prior to receiving an invitation to participate in UKB (which were sent out to individuals between the ages of 40 and 60), then they may be less likely to enrol.30 31path_MSH6 and path_PMS2 carriers may be under-represented in LS cohorts because lower penetrance obscures the autosomal dominant inheritance pattern used to identify affected families. Here, MSH2 is linked to cancer.