There is no evidence that the PRS modifies CRC risk for any gene (Wald test: path_MLH1: n=51, b=6.41, z=1.62, p=0.11; path_MSH2: n=35, b=1.47, z=0.28, p=0.78; path_MSH6: n=242, b=2.00, z=0.64, p=0.52; path_PMS2: n=366, b=3.98, z=0.95, p=0.34). The gene discussed is MSH2; the disease is colorectal carcinoma.