EC risk is greater than CRC risk in path_MSH6 carriers.22 24 CRC risk is less and generally later onset in path_MSH6 carriers than path_MLH1 and path_MSH2 carriers.22 24 25 EC and CRC risk is notably less for path_PMS2 carriers compared with carriers of path_MMR in other genes.22 This evidence concerns the gene MSH2 and colorectal carcinoma.