MLH1 and colorectal carcinoma: As in UKB, female carriers of path_MLH1 in PLSD have a lower cumulative CRC incidence by age 70 than male carriers: 42.1% (95% CI: 36.2% to 48.6%) in UKB vs 38.2% (95% CI: 23.25% to 58.39%) in PLSD.