Among emerged genes were CD160 which in RNA-seq and flow cytometry assays resulted as promoting regulation of glucose metabolism in NK cells through the PI3K/AKT/mTOR/s6k signaling pathway [37], PIEZO1 that was found overexpressed in isolated human islets of T2D patients and subjects with impaired glucose tolerance [40], and ALDH1A2—previously related to congenital heart disease [41]. The gene discussed is RPS6KB1; the disease is type 2 diabetes mellitus.