Analysis of DNAm-predicted blood cell counts [10] revealed that deceased T2D patients had a significantly higher amount of exhausted CD8 + T cells, marked as CD8 + CD28-CD45RA- (p = 0.020, Fig. 5B and Table S8), with no differences in terms of total CD8 + cells between groups. The gene discussed is CD8A; the disease is type 2 diabetes mellitus.