Further analysis of mouse tumor tissue sections using immunohistochemistry staining with cleaved-caspase 3 and ki67 showed that the positive rate of caspase-3 staining in the rs277646-T group was significantly lower than that in the rs277646-G group, while the positive rate of ki67 staining in the rs277646-T group was significantly higher than that in the rs277646-G group (Fig. 5d–g), indicating the T allele of rs277646 may promote the malignant phenotype of LUAD. Here, MKI67 is linked to neoplasm.