We further performed PDUI analysis of CISD2 and NIT2 in 56 paired samples, and the results also showed that the PDUI value of CISD2 and NIT2 were also significantly lower in LUAD tumor tissues (P = 8.80 × 10−17, P = 2.88 × 10−5) (Fig. 3i, j). Here, NIT2 is linked to neoplasm.