CISD2 and neoplasm: As shown in Fig. 2a–c, in adjacent non-tumor tissues (Rs = -0.540, P = 1.23 × 10−5), LUAD tumor tissues (Rs = -0.407, P = 9.50 × 10−21), and total tissues (Rs = -0.500, P = 1.28 × 10−35), we all observed a negative correlation between the PDUI value and gene expression level of CISD2. As the PDUI value increased, the expression of CISD2 decreased.