Proteins associated with a reduced risk of BCC were ACADVL (OR: 0.5709, CI: 0.4377 to 0.7446), GSK3A (OR: 0.5371, CI: 0.3904 to 0.7390), SHANK3 (OR: 0.8687, CI: 0.8147 to 0.9263) and STX8 (OR: 0.8203, CI: 0.7493 to 0.8980). The gene discussed is SHANK3; the disease is skin basal cell carcinoma.