The results showed that compared with the YC group, the TLR4 protein level in the OM group mice was sharply upregulated, accompanied by an increase in NF-κB phosphorylation level (p-NF-κB), while the administration of AP significantly inhibited the activation of the signaling pathway (Fig. 2I–K, P < 0.05). Here, TLR4 is linked to ocular melanoma.