Next, different AML cell lines that either naturally express high (THP-1, OCI-AML2, OCI-AML3, MonoMac6) or low (HEL, HL-60) levels of SAMHD1, stably overexpress SAMHD1 (HEL (high SAMHD1)), or in which SAMHD1 has been knocked out (THP-1 (SAMHD1 -/-)) were used (Supplementary Fig. 2). Here, RUNX3 is linked to acute myeloid leukemia.