SAMHD1 and acute myeloid leukemia: Because SAMHD1 plays such a critical role in dNTP homeostasis, we conducted a proof-of-concept study to genetically minimize the SIV-based VLP [6] to create a safer and simpler VLP and test its functional efficacy to transiently degrade SAMHD1 and enhance Ara-C cytotoxicity in AML cell lines and primary AML blasts.