IL17A and premature menopause: After preliminary mining of the comorbid genes of POF and DED, we performed gene enrichment analysis and functional annotation and found that the comorbidity mechanism of POF and DED was predominantly related to DNA replication (Fig. 12A, a figure from the KEGG pathway database41), cell cycle (Fig. 12B, a figure from the KEGG pathway database41), and the IL-17 signaling pathway.