PLK1 and premature menopause: The expression levels of these pivotal genes were validated using the POF-related dataset GSE48873 and DED-related dataset GSE171043, suggesting that CDC20, CDCA8, PLK1, TOP2A, MCM5, MCM6, MCM7, MCM2, CENPA, FOXM1, GINS1, TIPIN, MAD2L1, and CDCA3 are potential comorbid genes in POF and DED.