For instance, in a nested case-control study of Japanese American men (N = 1050), CRP levels of >1.0 mg/L (vs. <0.34 mg/L) were associated with 2.8 times greater odds of all dementia subtypes after adjusting for sociodemographic conditions, behavioral factors, and APOE-ε4 carrier status37. This evidence concerns the gene CRP and dementia.