CD8+ cell lysing rate corresponding to protective or non-protective HLA alleles has been used as predictor of good or bad infection outcomes, because HIV elite controllers provide increased HIV-specific CD8+ T-cell cytotoxic potential (Collins et al. 2020; Monel et al. 2019; Woldemeskel et al. 2020; Hersperger et al. 2011). This evidence concerns the gene CD8A and infection.