We have further analyzed the effect on overall survival (OS) due to MSH3 Ala1045Thr and MSH6 557G > T polymorphism based on different histology subtypes of lung cancer, and our results concluded that there is no significant association between OS and MSH3 rs26279 and MSH6 557G > T polymorphism. The gene discussed is MSH3; the disease is lung carcinoma.