AKT1 and cancer: Also, Dong et al. provided evidence that M2 macrophage-derived VEGF could simultaneously increase the expression of prostate cancer-associated transcript 6 (PCAT6) and VEGFR-2 through miR-4723-5p sponging, thereby enhancing tumor angiogenesis through the activation of VEGFR-2/Akt/mTOR signaling pathway [55, 78].