It has been shown that inhibition of tumor acidosis by adenylyl cyclase inhibitor MDL-12 induces NOS, CXCL9, CXCL11, and TNF-α-expressing proinflammatory TAMs that are phenotypically similar to classical M1 macrophages, leading to suppression of tumor growth in B16 mouse melanoma [199]. This evidence concerns the gene CXCL11 and neoplasm.