M1 cells typically respond to harmful signals sent by interferon γ (IFN-γ) and exhibit heightened expression of inducible nitric oxide synthase (iNOS), reactive oxygen species (ROS), and interleukin 12 (IL-12), which primarily possess antitumor effects and aid in distinguishing tumor cells from normal cells [8, 9]. The gene discussed is NOS2; the disease is neoplasm.