Eight metabolites showed significant, natural, indirect effects in the association between MIND scores and overall cancer risk, where total cholines, omega-3 fatty acids, glucose, citrate, free cholesterol in IDL and total lipids in large HDL mediated 7.1%, 17.1%, 1.3%, 1.3%, 5.8% and 11.5% of the total effect respectively, while total lipids in VLDL and albumin masked 2.6% and 1.3% of the effect respectively. The gene discussed is ALB; the disease is cancer.