MYC and colorectal carcinoma: In our study, we found that knockdown of β-TrCP in CRC cells downregulated c-Myc protein and overexpression of β-TrCP had the opposite effect, but β-TrCP had no effect on c-Myc mRNA (Fig. 6E and Supplementary Fig. 6A), which is consistent with Popov’s study [26].