BTRC and colorectal carcinoma: To explore whether UBTD1 regulates c-Myc protein level via β-TrCP, we interfered with β-TrCP expression in UBTD1 overexpressing CRC cells, and found that β-TrCP interfering could reverse the increased level of c-Myc protein caused by UBTD1 overexpression (Fig. 6F).