BTRC and colorectal carcinoma: Additionally, we verified that β-TrCP knockdown could downregulate c-Myc at the protein level, and overexpression of UBTD1 cannot upregulate c-Myc at the protein level in β-TrCP depleted CRC cells, indicating that β-TrCP was essential for UBTD1 to upregulate c-Myc protein.