In our study, we screened many glycolysis-related genes (HK1, HK2, LDHA, LDHB, ALDOA, and GLUT3), and identifed HK2 as a downstream effector gene for the enhanced glycolysis, which was upregulated by UBTD1 overexpression in CRC cells. Here, LDHB is linked to colorectal carcinoma.