Since previous studies demonstrated that UBTD1 is involved in UPS-mediated protein degradation, and UBTD1 was found to regulate c-Myc protein level but not mRNA level in our study, we speculate that UBTD1 may regulate c-Myc protein by affecting the UPS-mediated c-Myc degradation in CRC. This evidence concerns the gene UBTD1 and colorectal carcinoma.